This year the Westward Journey Nickel Series™ features a new obverse of Jefferson and two new reverse designs, the "American Bison" and the "Ocean in View." This set includes six nickels, offering both nickel designs for 2005. Included are two uncirculated Philadelphia "P" mint mark nickels, two uncirculated Denver "D" mint mark nickels, and two proof San Francisco "S" mint mark nickels. The coins are sealed in a clear, protective lens.

The obverse design for the 2005 nickels bears for the first time in 67 years, a new likeness of America's third president, Thomas Jefferson. The "Liberty" inscription on the coin is based upon Jefferson's own handwriting. The design is based on the marble bust of Jefferson by the French sculptor Jean-Antoine Houdon, completed in 1789. The design was made age-appropriate to his presidency by utilizing later paintings by Gilbert Stuart and Rembrandt Peale.

The first of two new reverses on the 2005-dated nickel features the American bison, recognizing the American Indians and wildlife encountered by the Lewis and Clark expedition. Expedition journals described the buffalo, and it was an animal of great significance to many American Indian cultures.

The second new reverse features a scene of western waters and an inscription reflecting an excited entry in the journal of Captain William Clark on November 7, 1805. The design visually depicts the expedition's exultation on believing they had finally reached the Pacific Ocean after so many months of arduous travel.