In late 2004 a second Jefferson nickel was released. The new reverse of the second 2004-dated nickel features an image depicting an angled view of the keelboat with full sail that transported members of the Lewis and Clark expedition and supplies as they traveled the rivers of the Louisiana Territory in search of a northwest passage to the Pacific Ocean. Captains Meriwether Lewis and William Clark are in full uniform in the bow.
Mintage:
| Philadelphia | Denver | Proof |
| 366,720,000 | 344,880,000 | 1,789,488 |