The first of two new reverses on the 2004-dated Jefferson nickel will feature a rendition of the reverse of the original Indian Peace Medal commissioned for Lewis and Clark's expedition, bearing the likeness of America's third president on one side, and symbols of peace and friendship on the other. The medals were presented to Native American chiefs and other important leaders as tokens of goodwill at treaty signings and other events.
The design, by United States Mint sculptor/engraver Norman E. Nemeth, features two hands clasped in friendship - one with a military uniform cuff, symbolizing the American government, and the other with a silver band adorned with beads and a stylized American eagle, representing the Native American community with whom the United States sought good relations.
Mintage:
| Philadelphia | Denver | Proof |
| 361,440,000 | 372,000,000 | 1,789,488 |