The San Antonio Missions National Historical Park (Guam) 2019 quarter is the fourth in 2019 and 49th overall in the America the Beautiful Quarters Program.
This design depicts elements of the Spanish Colonial Real coin to pay tribute to the missions. Within the quadrants are symbols of the missions: wheat symbolizes farming, the arches and bell symbolize community, a lion represents Spanish cultural heritage, and a symbol of the San Antonio River represents irrigation methods and life-sustaining resources. Inscriptions are "SAN ANTONIO MISSIONS," "TEXAS," "2019," and "E PLURIBUS UNUM."
Mintage:
| Philadelphia | Denver | San Francisco | West Point | Clad Proof | Silver Proof |
| 142,800,000 | 129,400,000 | 853,620 | 2,000,000 | 654,875 | 501,621 |